May 21, 2022

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Turning off genes that favor glioblastoma: This is how science is trying to tackle more aggressive and deadly brain tumors

A short-chain amino acid developed by an international group of researchers led by the University of Surrey in the UK capable of inhibiting the activity of Hox genes could spark a potential therapy against glioblastoma multiforme.


We may have found a file potential ally against the glioblastomaone of the biggest problems in medicine.

Boogie, yes. This is amazing Aggressive form of brain tumor Affect the The central nervous system It originates in girlwhich is a group of cells that support neurons, not only 45% for all brain tumors.

It is a malignant tumor that mainly affects Da 65 and over Don, however, spared the band the most smallwhere it is not very rare, but above all it is distinguished by it Life expectancy is definitely low. Unfortunately, those who suffer from it never outgrow Three years From the diagnosis: Five-year survival is only about 5% of people. from the public.

a short chain amino acids According to an international group of researchers led byUniversity of Surreyin the United Kingdom, could become the basis for a potential treatment against glioblastoma multiforme because it would effectively inhibit the activities of Hox . genes: those, that is, responsible for growth of this brain tumor.

Hox genes play a critical role in healthy growth Brain tissue is usually silenced at birth, but when improperly activated it can do its job On the contraryin favor of the development and progression of tumors located in the brain.

Science has always realized that dysregulation of these genes is closely related to glioblastoma multiforme but until now we did not know, basically, how to intervene in this mechanism.

As explained in the magazine BMC . CancerScientists have come up with one compound Specifically targeting these genes. Basically, this short chain of amino acids is called HTL-001 Focuses on the overexpression of Hox genes by blocking the interaction between Proteins that it The cofactor is called PBXstimulating cancer cellsApoptosisie, cellular suicide.

After testing on animal models (mice), the researchers note that their ‘molecule’ was able to deliver a Better control of tumor masses Also increase survival the animals themselves.

“While we are still at the beginning of the process, our seven-year project presents A glimmer of hope To find a solution to the dysregulation of the Hox gene, which is linked to the growth of glioblastoma multiforme and other types of cancer, which has been shown to be a target Elusive for many years “ He explained Hardif Pandaproject leader and professor of oncology at the University of Surrey.

source | “HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme” Published April 13, 2022 in the journal BMC . Cancer

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