The secret to fighting Alzheimer's: olive oil

Alzheimer's disease is a disease that affects many people around the world. This terrible disease can affect you in several ways: It can make you a very aggressive person or a very innocent person. Accordingly, memory loss. There is a lot of research to be able to deal with this very common disease that affects young and younger people. One of the studies conducted by scientists Drand the Lewis Katz School of Medicine at Temple University (Lexum), Philadelphia. In this study/research I used EVOO (extra virgin olive oil)since then It is a food that contains antioxidants that protect cells and help fight aging Cardiovascular diseases, Among many other benefits. In this study they proved that, Extra virgin olive oil helps maintain memory and protect the brain from Alzheimer's disease.

In a new study on mice published online in Journal of “Cell Aging”, LKSOM scientists show this Another group of diseases associated with aging can be added to this list: topopathies, which are characterized by the gradual accumulation of an abnormal form of a protein called tau in the brain. this process It leads to decreased mental function or dementia. These findings are the first to suggest that olive oil can defend against a specific type of mental impairment associated with tauopathy known as tauopathy. Frontotemporal dementia.

Alzheimer's

Alzheimer's disease is itself a form of dementia. It mainly affects the hippocampus, which is the memory storage center in the brain. Frontotemporal dementia affects areas of the brain near the forehead and ears. Symptoms usually appear between the ages of 40 and 65, and include personality and behavior changes, difficulties with language and writing, and impaired memory and ability to learn from past experiences..

Principal Investigator Domenico Pratico, Scott Richards, President of Northstar Alzheimer's Research FoundationA professor in the departments of pharmacology and microbiology and director of the Alzheimer's Center at Temple at LKSOM, describes the new work as providing another piece in the story about… The ability of pure olive oil to prevent cognitive impairment and protect joints where nerve cells are located They come together to exchange information, which is known as a synapse.

Loly Doliva is on the verge of more

“Olive oil has been part of the human diet for a long time and has many benefits for humans Health, for reasons we still do not fully understand – he admits. The discovery that olive oil can protect the brain from various forms of dementia gives us the opportunity to learn more about the mechanisms by which it works to support brain health.

In previous worksUsing a mouse model in which animals are expected to develop Alzheimer's disease, Dr. Pratico's team It showed that olive oil present in the diet protected young mice from poor memory and learning Infillin. particularly, When the researchers looked at the brain tissue of mice fed olive oil, they did not see the typical features of cognitive impairment. Especially amyloid plaques, which are “sticky” proteins that comprise communication pathways between nerve cells in the brain. On the other side, The animals' brains appeared normal.

The team's new study shows that the same applies to DrMice engineered to develop tauopathy. In this mouseThe normal tau protein becomes defective and builds up in the brain, forming harmful tau deposits, also called tangles. Tau deposits, similar to the amyloid plaques in Alzheimer's disease, block neural communication and thus impair thinking and memory, leading to frontotemporal dementia.

Tau mice were fed a diet supplemented with EVOO at an early agecomparable to about 30 or 40 years in humans. After six months, When the lifespan of mice was equivalent to 60 years in humans, People susceptible to tauopathy saw a 60% reduction in harmful tau depositscompared to littermates who were not fed EVOO. The animals on the EVOO diet also performed better on memory and learning tests than the animals deprived of EVOO.

When Dr. Pratico and his colleagues examined the brain tissue of mice that had been fed EVOO, They found that improved brain function was likely facilitated by healthier synaptic function, which has also been associated with higher than normal levels of a protein known as complex-1. It is known that Compound-1 plays an essential role in maintaining healthy synapses.

The team investigatedWe now plan to explore what happens when EVOO is fed to older animals that have begun to develop tau deposits and signs of cognitive impairment, more closely mirroring the clinical scenario in humans. “We are particularly interested in knowing whether EVOO is able to reverse tau pathology and ultimately treat tauopathy in older mice,” concludes Dr. Pratico.