August 10, 2022

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Science, of synthetic DNA stem cells to study ‘architect genes’

creation of gods Synthetic Hox genes, sets of genes that control entire sets of other genes, in order to study the functioning of these structures and to investigate their role in the development of specific genetic conditions. This is the goal that led a study published in the journal Sciences, conducted by scholars from Grossman School of Medicine at New York Universitywho made Synthetic DNA from stem cells. The authors explained that these findings confirm that Hox genes help cells navigate the body. These “architectural” genes determine where cells must place themselves and the function they must perform within the body. “If Hox genes fail – as Esteban Mazzoni of New York University explains – due to poor regulation or mutation, cells can be lost, causing conditions such as tumors, birth defects or spontaneous abortions. Understanding the mechanisms associated with these genes is fundamental to understanding how diseases develop. genetics.” However, the Hox genes, experts say, are difficult to study because they are organized into clusters and do not contain repeating elements. “Writing or building new pieces of the genome thanks to CRISPR technology – adds Mazzoni – can help us discover the smallest unit of the genome needed for cell orientation.” The team led by Mazzoni E Jeff Boeke, He made long strands of synthetic DNA by copying genetic information from the Hox genes of a mouse model. The researchers then inserted the genetic material into the animals’ pluripotent stem cells. Thanks to this approach – Boeke comments – we can understand how Hox genes help cells learn and remember where they are. Our work indicates that the compact nature of Hox clusters plays an important role in regulating the functions of these genes. Synthetic DNA technology will be of great value in the study of genetically complex diseases.”

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