Researchers from12 October Hospital in Madrid You have identified the cause that causes A A type of malignant brain tumorknown as Glioblastomabe more aggressive and cause less survival Role Among women, the reason that generates this difference is the necrosis or death of cancer cells, which leads to an inflammatory reaction characterized by the infiltration of a type of immune system cell, called myeloid suppressor cell (MDSC), which instead of attacking malignant cells, helps them grow, according to the Madrid Hospital reports.
These cells will be more present in men due to the fact that the necrosis and inflammation resulting from the tumor is much greater. According to Dr. Berta Segura, a postdoctoral researcher in the Neuro-Oncology Research Group at the October 12 Hospital Research Institute, differences in the incidence and severity of different types of cancer between men and women are widely known, but in most cases the reason for creating Specific treatment for each gender.
Glioblastoma is the most common malignant brain tumor and is a good example. In this context, the aim of this study was to investigate the tumor processes that explain these differences based on sex. The researchers explain that this is a retrospective study of patients with glioblastoma who were stratified by sex and analyzed a group of 73 tumors.
They noticed that when a tumor generates necrosis, substances are released that activate the process of recruiting the immune system. In men, greater necrosis occurs, generating a more toxic microenvironment and a more massive and aggressive inflammatory response by immune cells called MDSCs.
They describe that MSDCs – immunosuppressive cells – are produced in the bone marrow and have the ability to suppress the function of various components of the immune system, so that they help their growth rather than attack the tumor.
The origin of the more aggressive gliomas in the men’s group is due to the inability of the tumor to generate functional tumor blood vessels, which provide the delivery of necessary oxygen and nutrients to the cells, subsequently leading to tumor necrosis, the researchers point out.
However, “what is even more surprising is that there is a group of men who do not have these tumor characteristics and this brain tumor is much less aggressive and becomes very similar to that found in women,” notes Dr. Segura.
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