The beneficial effects of moderate exercise are beneficial to those who exercise, but researchers have found that its benefits extend to children and are passed on as an inheritance even to the second generation, that is, the grandchildren.
This has been verified by a team from the institute. Kajal To the Supreme Council for Scientific Research (CSIC) Led by researcher Jose Luis Trejo, who directs the Lifestyle and Cognition group, the study results a job It was published in Journal of Neurology of the American Society Neurology.
Like the benefits, the authors a job They found that the harmful effects of a sedentary lifestyle also affect offspring through the same mechanisms.
Researchers have shown in mice that moderate training has a longer-lasting effect than previously thought, benefiting even the second generation, and that it is likely mediated by a small set of “microRNAs” that work by passing from parents to offspring over generations.
These are “micro RNAs” (miRNAs), the institute explained. Kajal In a press release issued today, they said: rabbit (RNA) is a small molecule that participates in the physiological processes that govern normal brain functions and is capable of controlling gene expression, forming a genetic mechanism for inheritance that is transmitted to future generations through sex cells.
Epigenetics consists of changes in gene function, caused by several mechanisms; these changes activate or deactivate genes without modifying the DNA sequence, in response to environmental factors, such as diet or exercise.
It was already known that “micro RNAs,” discovered in 1993, are involved in physiological processes that control normal brain function and that dysregulated “micro RNA” profiles are associated with the development and progression of neurodegenerative diseases such as Alzheimer’s disease.
Although they have not studied this mechanism in female mice due to its difficulty. Gran To distinguish the effects Non-genetic When it comes to exercise, the researchers believe a similar mechanism will work in mothers who exercise, with “micro RNA” being transferred to their eggs.
The institute highlighted that this discovery is important due to the current lack of evidence supporting the intergenerational transmission of positive outcomes derived from lifestyle interventions targeting the brain and cognition. Kajal.
“Addressing this issue is crucial, as it can provide valuable information for designing more effective public health policies in the face of the alarming increase in sedentary lifestyles,” said José Luis Trijo.
The researchers also found that not all of the beneficial effects inherited by physically active offspring were maintained in the offspring if their parents were inactive, suggesting that there is a suddenly Part of the beneficial effect of exercise is inherited from ancestors when subsequent generations abandon physical activity.
Results of this a jobwhose first authors are Elisa Sentado I Patricia TezanosIt can also be interpreted as evidence that the negative impact of a sedentary lifestyle on the health of the body and brain can be passed on to subsequent generations.
The researchers highlighted that the results reached in this regard a job They can be valuable in supporting evidence-based health policies in contexts such as development, disease and ageing.
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