One study revealed that age-related loss of the Y chromosome in men is associated with scarring of the heart muscle and an increased risk of heart failure. The findings could explain why men tend to die, on average, seven years earlier than women
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there Loss of the male sex chromosome Because of age, it causes scarring of the heart muscle and can lead to early death, and this is what results in new Search subordinate University of Virginia College of Medicine.
This finding may help explain why men die, on average, many years earlier than women.
The new research suggests that men with a loss of the Y chromosome, which is estimated to include 40 percent of 70-year-olds, may particularly benefit from an existing drug that targets dangerous tissue scarring.
The drug can help counteract the harmful effects of chromosomal loss, effects that can occur not only in the heart but also in other parts of the body.
Especially after the age of 60, men die faster than women. It’s as if they are aging biologically faster. While women have two X chromosomes, men have one X and one Y. But many men begin to lose the Y chromosome in a small portion of their cells as they age. This seems to be especially true for smokers.
The loss occurs mainly in cells that undergo rapid turnover, such as blood cells.
Scientists previously noted that men with a loss of the Y chromosome are more likely to die at an earlier age, and to suffer from diseases associated with aging such as Alzheimer’s disease.
In the new study, the team of researchers used CRISPR gene-editing technology to better understand the effects of loss of the Y chromosome in the blood.
They found that this phenomenon accelerates age-related diseases, makes them more likely to scar the heart, and leads to premature death.
The scientists also looked at the effects of losing the Y chromosome in men. They conducted three analyzes of data collected by the British Biobank, and found that loss of the Y chromosome is associated with cardiovascular disease, heart failure, and therefore premature death.
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source: Sciences
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