study Hebron Valley an offer Symbiotic potential, A combination of Prebiotics and probiotics, for youTreating Irritability in Adults with ADHD (ADHD) and borderline personality disorder (BPD). The findings are published in the journal Brain, Behavior and Immunity. Irritability is a complex and often persistent symptom that impacts the quality of life of patients with ADHD and BPD and, in severe cases, can increase the risk of suicide. The work shows the benefits of taking a symbiotic drug, which combines a community of bacteria with sugars that act as nutrients, to reduce irritability, improve emotional control and reduce attention problems.
This study deals with a Symptoms are less common, including irritability.This is done through a “basket” clinical trial, which allows for this.Study of two different disorders but with common symptoms. These types of studies are common in oncology to study different tumors with common characteristics.
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Previous studies have suggested the potential of symbiosis in the treatment of emotional dysregulation associated with ADHD. In this context, the Vall d’Hebron team promoted a clinical trial to explore the benefits of symbiosis for the treatment of patients with irritability. Patients from the Hospital de Barcelona, Semmelweis University (Budapest, Hungary) and Goethe University Hospital Frankfurt (Germany) participated in the study.
the job It included 180 patients aged between 20 and 65 years.Of these, 113 had ADHD, 44 had borderline personality disorder, and 23 had both. All had symptoms of irritability and most were already taking other medications. Half the patients received a placebo and the others a symbiotic, a combination of four types of bacteria (probiotics) and a group of sugars that act as nutrients for their growth (prebiotics).
Researchers analyzed response to treatment after 10 weeks and considered a good response to treatment if there was clinical improvement in symptoms of irritation, based on the judgment of medical professionals and the patient’s experience.
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The researchers noted that 19 patients (11% of the total) had low levels of irritation: 15 of them (79%) received the complementary treatment while only four (21%) received the placebo. In all cases, the treatment was well tolerated, with few side effects.
“Current treatments do not significantly improve symptoms of irritability,” notes Dr. Gara Arteaga Henriquez, of the hospital’s psychiatric service and researcher at the Vall d’Hebron Research Institute (VHIR), in statements compiled by the center. Dr. Arteaga adds that the study “provides promising preliminary evidence for the use of symbiotics in the treatment of irritability and other emotional symptoms in adults with ADHD and borderline personality disorder.
The study looked at the relationship between levels of certain immune system molecules in the blood and the success of the treatment to understand why some patients respond to symbiotics and others do not. “We think that symbionts may act as immune system regulators and that the response to these treatments is influenced by the underlying inflammatory conditions of each individual,” the researcher notes. Among the molecules studied, RANK-L stands out: patients with low levels responded better to symbiont therapy, the results showed.
The authors emphasize the need for further research. “These results open the door to new approaches to personalized treatment based on the modification of the intestinal microbiota for patients who do not respond to conventional treatments for irritability,” emphasizes Dr. Josep Antoni Ramos Quiroga, head of the Val Psychiatric Service in Hebron and the Psychiatry, Mental Health and Addiction Group of the VHIR.
Two different disorders with common characteristics
Attention deficit hyperactivity disorder (ADHD) primarily affects attention, impulsivity, and motor control. It is primarily diagnosed in childhood, although in many cases its effects continue into adulthood.
Borderline personality disorder (BPD), on the other hand, is characterized by significant emotional instability, intense and volatile patterns of interpersonal relationships, and changes in the perception of one’s own identity.
Although the specific symptoms of ADHD and BPD can vary greatly, both disorders share a partial biological basis and some common features, such as persistent irritability and emotional dysregulation.
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